Botulinum toxin for motor and phonic tics

  • Home / Botulinum toxin for motor and phonic tics

Botulinum toxin for motor and phonic tics

Pandey S, Srivanitchapoom P, Kirubakaran R, Berman BD

Review question: How safe and effective is botulinum toxin, compared to placebo or other medications, in treating motor and phonic tics in Tourette’s syndrome?

Background: People with Tourette’s syndrome often make repetitive and sudden movements (motor) or vocal noises (phonic) called tics. Botulinum toxin injections are used to treat motor and phonic tics in patients with Tourette’s syndrome. They are thought to weaken the mechanism in the body that makes the tics happen. There are conflicting reports regarding their effectiveness.

Study characteristics: The review authors summarised information from one clinical trial that compared botulinum toxin to a placebo, to treat tics in adults with Tourette’s syndrome.

Key results: We found one small study. The study was limited by the number of participants (N = 18), who mainly had mild tics. We are very uncertain about the effects of botulinum toxin injections on reducing tic frequency and severity, and measures of overall well-being. Some participants experienced harms, which included weakness, restlessness, and neck discomfort following the injection. We do not know from the study whether participants who received the injection developed resistance to the botulinum injections, which would make them less effective over time.

The evidence is current to 25 October 2017.

About Post Author

Medical CPD & News

The Digitalis CPD trawler searches the web for all the latest news and journals.

Privacy Preference Center

Close your account?

Your account will be closed and all data will be permanently deleted and cannot be recovered. Are you sure?

Are you sure?

By disagreeing you will no longer have access to our site and will be logged out.