Image-guided surgery for brain tumours

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Image-guided surgery for brain tumours

Jenkinson MD, Barone D, Bryant A, Vale L, Bulbeck H, Lawrie TA, Hart MG, Watts C

Surgery has a key role in the management of many types of brain tumour. Removing as much tumour as possible is very important, as in some types of brain tumour this can help patients to live longer and to feel better. However, removing a brain tumour may in some cases be difficult because the tumour either looks like normal brain tissue or is near brain tissue that is needed for normal functioning. New methods of seeing tumours during surgery have been developed to help surgeons better identify tumour from normal brain tissue.

1. Is image-guided surgery more effective at removing brain tumours than surgery without image guidance?
2. Is one image guidance technology or tool better than another?

Study characteristics
Our search strategy is up to date as of July 2017. We found four trials looking at three different types of tools to help improve the amount of tumour that is removed. The tumour being evaluated was high-grade glioma. Imaging interventions used during surgery included:

• magnetic resonance imaging (iMRI) during surgery to assess the amount of remaining tumour;
• fluorescent dye (5-aminolevulinic acid) to mark out the tumour; or
• imaging before surgery to map out the location of a tumour, which was then used at the time of surgery to guide the surgery (neuronavigation).

All the studies had compromised methods, which could mean their conclusions were biased. Other studies were funded by the manufacturers of the image guidance technology being evaluated.

Key results
We found low- to very low-quality evidence that use of image-guided surgery may result in more of the tumour being removed surgically in some people. The short- and long-term neurological effects are uncertain. We did not have the data to determined whether any of the evaluated technologies affect overall survival, time until disease progression, or quality of life. There was very low-quality evidence for neuronavigation, and we identified no trials for ultrasound guidance. In terms of costs, a non-systematic review of economic studies suggested that compared with standard surgery use of image-guided surgery has an uncertain effect on costs and that 5-aminolevulinic acid was more costly than conventional surgery.

Quality of the evidence
Evidence for intraoperative imaging technology for use in removing brain tumours is sparse and of low to very low quality. Further research is needed to assess three main questions.

1. Is removing more of the tumour better for the patient in the long term?
2. What are the risks of causing a patient to have worse symptoms by taking out more of the tumour?
3. How does resection affect a patient’s quality of life?

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